Designed to be different

Startect uses
2 modes of action for effective worm control and greater sustainability

Startect kills worms in a truly unique way

  • Derquantel has a totally different mode of action to all other existing drenches.12
  • Blocks the nerve signals to the worm's muscles paralysing the worms body, resulting in death. The worm is then passed out of the sheep.
  • Abamectin kills worms in a totally different way. It paralysis the worm's throat so it can't eat and the worm dies. It is then passed out of the sheep.
  • Startect combines derquantel with abamectin to effectively kill worms using two modes of action, giving you a new level of confidence now and in the future.

Mode of action flowchart10,17

    1. 1. Derquantel binds to the muscle receptor
    2. 2. Blocks nerve signal
    3. 3. No contract/relax instruction received by the muscles
    1. 4. Muscles remain paralysed
    2. 5. Worms are unable to move, eat or lay eggs
    3. 6. Worms run out of energy and die, or are flushed out of the sheep
    1. 1. Abamectin binds to the glutamate-gated chloride channel (Glu-Cl) receptor on the worm's nerves
    2. 2. It stimulates the receptor (agonist), causing the channel to remain open (irreversible binding)
    3. 3. Chloride ions flow through the channel into the cell, causing hyper-polarisation
    1. 4. Nerve transmission and muscle contraction are impaired
    2. 5. Worms are unable to move, feed or lay eggs
    3. 6. Worms run out of energy and die, or are flushed out of the sheep

Mode of action by class14,17,18

CLASS MODE OF ACTION
Organophosphates (OP) Anticholinesterase (disrupts nerve transmission)
Benzimidazoles (BZ, whites) Tubulin binding (disrupts energy supply)
Macrocyclic Lactones (ML, mectins, e.g. Abamectin) Glutamate receptors, allows chloride influx into nerves blocking signals to muscles causing paralysis
Imidazothiazoles (Levamisole, clears) Nicotinic receptor agonist (stimulates muscle contractions, leading to paralysis)
Aminoacetonitrile derivatives (AADs, Monepantel) Nicotinic receptor agonist (stimulates muscle contractions, leading to paralysis)
SPIROINDOLES (SI, DERQUANTEL) NICOTINIC RECEPTOR ANTAGONIST (blocks nerve signals from reaching muscles, resulting in paralysis)

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